Melanosis coli 1
A 77-year-old white female patient was referred for colonoscopy in the work-up with iron deficiency anemia. The patient had never observed blood in her stool and testing for occult blood in the stool was negative. She reported a history of constipation for many years for which she had frequently resorted to laxatives.
The video recording shows various segments of the colon. The entire mucosal membrane is abnormal, exhibiting a brown, net-like discoloration. The blood vessels are recognizable in the mucosa.
Use of anthracene-containing laxatives over a period of many years can result in deposit of lipofuscin in the macrophages of the lamina propria. Once such laxatives are discontinued, there is a slow reduction in these deposits.