Liver and Bile
Eur J Gastroenterol Hepatol. 2023;35(1):80–8
Can albumin reduce the mortality of patients with cirrhosis and ascites? A meta-analysis of randomized controlled trials
Background: Albumin therapy in patients with decompensated liver cirrhosis has always been a controversial issue. This study aimed to investigate the efficacy and safety of albumin in reducing mortality and controlling complications in patients with liver cirrhosis and provide a reference for relevant decision-making.
Methods: Databases such as PubMed, Embase, and Web of Science were searched to collect eligible articles published before January 2022, which were analyzed by Revman 5.3.
Results: A total of 10 randomized controlled trials (2040 patients) were included. Based on the meta-analysis results, no significant difference in mortality was shown between the albumin administration group and the control group (hazard ratio [HR] = 1.01; 95% confidence interval [CI]: 0.97–1.05; p = 0.62). Subgroup analysis showed that albumin administration had no significant short-term or long-term survival benefits in patients with decompensated liver cirrhosis and increased the risk of pulmonary edema adverse reactions (relative risk [RR] = 3.14; 95% CI: 1.48–6.65; p = 0.003). Subgroup analysis based on albumin administration time showed that short-term (HR = 0.93; 95% CI: 0.76–1.13; p = 0.47) or long-term (HR = 0.97; 95% CI: 0.87–1.08; p = 0.58) administration of albumin could not significantly reduce the mortality of patients with decompensated liver cirrhosis. In contrast, albumin administration could significantly reduce the recurrence rate of ascites (RR = 0.56; 95% CI: 0.46–0.68; p = 0.000).
Conclusion: Short-term (< 1 month) or long-term (> 1 month) administration of albumin cannot significantly reduce the mortality of patients with decompensated liver cirrhosis, and a large amount of albumin infusion will increase the risk of pulmonary edema.