Colon to Rectum
Am J Gastroenterol. 2023;118(10):1848–54
Impact of submucosal saline injection during cold snare polypectomy for colorectal polyps sized 3–9 mm: A multicenter randomized controlled trial
Introduction: The role of submucosal injection during cold snare polypectomy (CSP) remains uncertain. In this study, the authors investigated the impact of submucosal saline injection during CSP for colorectal polyps sized 3–9 mm.
Methods: This was a multicenter randomized controlled trial conducted in 6 Chinese centers between July and September 2020. Patients with non-pedunculated colorectal polyps sized 3–9 mm were randomized in a 1:1 ratio to either CSP with submucosal injection (SI-CSP) or conventional CSP (C-CSP). The primary outcome was the incomplete resection rate (IRR). Secondary outcomes included procedure time, intraprocedural bleeding, delayed bleeding, and perforation.
Results: 150 patients with 234 polyps in the SI-CSP group and 150 patients with 216 polyps in the C-CSP group were included in the analysis. The IRR was not decreased in the SI-CSP group compared with that in the C-CSP group (1.7% vs. 1.4%, p = 1.000). The median procedure time in the SI-CSP group was significantly longer than that in the C-CSP group (108 seconds vs. 48 seconds, p < 0.001). The incidences of intraprocedural bleeding and delayed bleeding were not significantly different between the 2 groups (p = 0.531 and p = 0.250, respectively). There was no perforation in either group.
Discussion: Submucosal saline injection during cold snare polypectomy for colorectal polyps sized 3–9 mm did not decrease the incomplete resection rate or reduce adverse events but prolonged the procedure time.