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Clin Gastroenterol Hepatol. 2023;21(3):761–70.e13

Alayo QA, Loftus EV, Jr., Yarur A, Alvarado D, Ciorba MA, de las Fuentes L, Deepak P

Inflammatory bowel disease is associated with an increased risk of incident acute arterial events: Analysis of the United Kingdom Biobank

Background and aims: Population-based studies have suggested an increased risk of acute arterial events (AAEs) in patients with inflammatory bowel disease (IBD). The authors aimed to assess the risk of incident AAEs and premature AAEs, adjusted for diet, physical activity, and inflammation biomarkers, in participants with IBD in the United Kingdom Biobank (UKB)
Methods: UKB participants with IBD and without prevalent AAEs at enrollment were matched to random non-IBD controls. A Cox regression model, adjusting for baseline cardiovascular and IBD risk factors, diet, physical activity, and high-sensitivity C-reactive protein (CRP), estimated adjusted hazard ratios (aHRs) for association between IBD and AAEs or premature AAEs (age < 55 years for men and < 65 years for women). Predictors of AAEs within the IBD cohort were identified in a Cox model adjusting for disease severity (IBD-related hospitalizations or surgeries).
Results: Among 455,950 UKB participants, 5094 with IBD were matched to 20,376 non-IBD controls. After a median follow-up period of 12.4 years, participants with IBD had a higher incident rate of AAE (924.1 vs. 730.9 per 100,000 person years; p < 0.001), risk of all AAEs (aHR = 1.19; 95% confidence interval [CI]: 1.08–1.31; p < 0.001), and premature AAEs (aHR = 1.38; 95% CI: 1.11–1.72; p = 0.001). High-sensitivity CRP levels (highest quartile: aHR = 1.53; 95% CI: 1.15–2.03) and disease severity (aHR = 5.40; 95% CI: 4.03–7.22) were independent predictors of AAEs in IBD.

Conclusions: In a prospective cohort, there was an increased risk of incident acute arterial events (AAEs) and premature AAEs in participants with inflammatory bowel disease (IBD). Beyond traditional AAE risk factors, quantifiable indices of IBD disease activity and severity were independent predictors of AAEs.

P. Deepak, M.D., Associate Professor of Medicine, Inflammatory Bowel Diseases Center, Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA,
E-Mail: deepak.parakkal@wustl.edu

DOI: DOI: 10.1016/j.cgh.2022.08.035

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Post-COVID-19 irritable bowel syndrome

Gut. 2023;72(3):484–92

Marasco G, Cremon C, Barbaro MR, Cacciari G, Falangone F, Kagramanova A, Bordin D, Drug V, Miftode E, Fusaroli P, Mohamed SY, Ricci C, Bellini M, Rahman MM, Melcarne L, Santos J, Lobo B, Bor S, Yapali S, Akyol D, Sapmaz FP, Urun YY, Eskazan T, Celebi A, Kacmaz H, Ebik B, Binicier HC, Bugdayci MS, Yağcı MB, Pullukcu H, Kaya BY, Tureyen A, Hatemi İ, Koc ES, Sirin G, Calıskan AR, Bengi G, Alıs EE, Lukic S, Trajkovska M, Hod K, Dumitrascu D, Pietrangelo A, Corradini E, Simren M, Sjölund J, Tornkvist N, Ghoshal UC, Kolokolnikova O, Colecchia A, Serra J, Maconi G, De Giorgio R, Danese S, Portincasa P, Di Sabatino A, Maggio M, Philippou E, Lee YY, Salvi D, Venturi A, Borghi C, Zoli M, Gionchetti P, Viale P, Stanghellini V, Barbara G; GI-COVID19 study group

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Long-term gastrointestinal sequelae following COVID-19: A prospective follow-up cohort study

Clin Gastroenterol Hepatol. 2023;21(3):789–96.e1