Esophagus to Small Intestine

Am J Gastroenterol. 2022;117(8):1246–54

Wang KK, Kim K, Bancila L, Lew D, Larson BK, Kim S, Lee JY, Gaddam S, Lo SK

Novel endoscopic polypectomy surveillance technique for fundic gland polyps in familial adenomatous polyposis can improve early detection of dysplasia and gastric cancer


Introduction: Fundic gland polyps (FGPs) are commonly found in patients with familial adenomatous polyposis (FAP) and are considered benign. Biopsies are not routinely performed, and conventional forceps may be time-consuming and/or yield non-representative histology. The purpose of this study was to evaluate the role of a novel endoscopic polypectomy surveillance (EPS), a large volume cold-snare polypectomy technique of random FGPs, in the incidence of dysplasia and gastric cancer (GC) in FAP.
Methods: This is a retrospective longitudinal cohort of patients with FAP referred to a tertiary care center for duodenal adenoma surveillance and who underwent EPS of FGPs between 2001 and 2019. Demographic, endoscopic, and clinicopathologic information was reviewed.
Results: 35 patients with FAP were identified at initial endoscopy by the mean age of 43.4 ± 12.8 years. 113 surveillance endoscopies were performed in total using EPS. Dysplasia of FGPs was present on initial esophagogastroduodenoscopy in 7 patients (20%), and 13 additional patients (46.4%) progressed to low-grade dysplasia. Three patients (15%) who subsequently had progression to GC were found to have signet ring cell cancer within the foci of FGPs through EPS. One patient presented as metastatic GC. Progression from non-dysplastic FGP to low-grade dysplasia occurred over 63 ± 46.3 months with further progression to GC over 34 ± 8.5 months. Endoscopic risk factors for cancer were polyps > 10 mm in size (p < 0.001) and carpeting of polyps (p < 0.001). The 5-year cumulative incidence of developing dysplasia was 35.7%.

Discussion: The authors identified that the incidence of dysplasia and gastric cancer (GC) is higher than previously reported in patients with familial adenomatous polyposis. Their study used a novel endoscopic polypectomy surveillance (EPS) technique and was able to identify GC within the foci of fundic gland polyps (FGPs). Upper endoscopic guidelines should include a more rigorous sampling method for FGPs, such as EPS, to optimize early detection of dysplasia and GC.

K.K. Wang, M.D., Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA,
E-Mail: kelly.wang@cshs.org

DOI: 10.14309/ajg.0000000000001833

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