Liver and Bile
Dig Liver Dis. 2023;55(10):1318–27
Treatment response to ursodeoxycholic acid in primary biliary cholangitis: A systematic review and meta-analysis
Background: Several ursodeoxycholic acid (UDCA) treatment response definitions have been introduced in primary biliary cholangitis (PBC). However, the lack of a gold standard results in heterogeneity in second-line treatment research and clinical practice.
Aims: This study aimed to explore which UDCA treatment response end point serves as the most accurate predictive model of long-term outcome.
Methods: A systematic review and meta-analysis of UDCA treatment response end points (and corresponding validations) were performed.
Results: 16 individual UDCA treatment response end points and 96 external validations were found. Barcelona, Paris-1, Paris-2, Rotterdam, Toronto and GLOBE and UK-PBC Risk Scores are currently most robustly validated in external populations. The results show that the continuous models (GLOBE and UK-PBC Risk Scores) serve as the most accurate predictive models. Besides standard UDCA treatment response end points, the alkaline phosphatase and total bilirubin normalization has been suggested as a new therapeutic target.
Conclusions: The GLOBE and UK-PBC Risk Scores are the most suitable for the real-world allocation of second-line therapies (obeticholic acid and fibrates). However, in the wake of the recent findings, alkaline phosphatase and total bilirubin normalization should be the primary outcome in trial research in primary biliary cholangitis.