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Falk Gastro Review Journal

Current science, compiled for you from the multitude of scientific publications – this is the Falk Gastro Review Journal.

Dunkel- bis hellblaue Grafik einer Tonspur-Frequenz auf orangem Hintergund.

The latest issues

Edition 1/2026

Edition 4/2025

Edition 3/2025

Find here all FGR publications since mid-2022 selected and reviewed from international medical journals. Click here above to browse the individual quarterly issues or use the filters below or click chronologically through all articles.

All articles

Colon to Rectum

A phase 2, multicentric, randomized, double-blind, placebo-controlled, proof of concept study of efficacy and safety of rifamycin SV-MMX 600 mg tablets administered three or two times daily to patients with diarrhea-predominant irritable bowel syndrome

Am J Gastroenterol. 2025;120(7):1605-1614

Balsiger LM, Santos J, Serra J, Piessevaux H, Baert D, Storr M, Basilisco G, Mazzetti A, Moro L, Gerloni M, Longo L, Gentili A, Tack J

Colon to Rectum

Effect of gluten and wheat on symptoms and behaviours in adults with irritable bowel syndrome: A single-centre, randomised, double-blind, sham-controlled crossover trial

Lancet Gastroenterol Hepatol. 2025;10(9):794-805

Seiler CL, Rueda GH, Miranda PM, Nardelli A, Borojevic R, Hann A, Rahmani S, De Souza R, Caminero A, Curella V, Neerukonda M, Vanner S, Schuppan D, Moayyedi P, Collins SM, Verdu EF, Pinto-Sanchez MI, Bercik P

Colon to Rectum

Robotic versus laparoscopic surgery for middle and low rectal cancer: The REAL randomized clinical trial

JAMA. 2025 Jul 8;334(2):136-148

Feng Q, Yuan W, Li T, Tang B, Jia B, Zhou Y, Zhang W, Zhao R, Zhang C, Cheng L, Zhang X, Wei Y, Liang F, He G, Xu J; REAL Study Group

Colon to Rectum

Encorafenib, cetuximab, and mFOLFOX6 in BRAF-mutated colorectal cancer

N Engl J Med. 2025;392(24):2425-2437

Elez E, Yoshino T, Shen L, Lonardi S, Van Cutsem E, Eng C, Kim TW, Wasan HS, Desai J, Ciardiello F, Yaeger R, Maughan TS, Morris VK, Wu C, Usari T, Laliberte R, Dychter SS, Zhang X, Tabernero J, Kopetz S; BREAKWATER Trial Investigators

Colon to Rectum

Structured exercise after adjuvant chemotherapy for colon cancer

N Engl J Med. 2025;393(1):13-25

Courneya KS, Vardy JL, O’Callaghan CJ, Gill S, Friedenreich CM, Wong RKS, Dhillon HM, Coyle V, Chua NS, Jonker DJ, Beale PJ, Haider K, Tang PA, Bonaventura T, Wong R, Lim HJ, Burge ME, Hubay S, Sanatani M, Campbell KL, Arthuso FZ, Turner J, Meyer RM, Brundage M, O’Brien P, Tu D, Booth CM; CHALLENGE Investigators

Colon to Rectum

Nonoperative management of mismatch repair-deficient tumors

N Engl J Med. 2025;392(23):2297-2308

Cercek A, Foote MB, Rousseau B, Smith JJ, Shia J, Sinopoli J, Weiss J, Lumish M, Temple L, Patel M, Wilde C, Saltz LB, Argiles G, Stadler Z, Artz O, Maron S, Ku G, Gu P, Janjigian YY, Molena D, Iyer G, Coleman J, Abida W, Cohen S, Soares K, Schattner M, Strong VE, Yaeger R, Paty P, Shcherba M, Sugarman R, Romesser PB, Zervoudakis A, Desai A, Segal NH, El Dika I, Widmar M, Wei I, Pappou E, Fumo G, Aparo S, Gonen M, Gollub M, Jayaprakasam VS, Kim TH, Garcia Aguilar J, Weiser M, Diaz LA, Jr.

Colon to Rectum

Multicentre randomised controlled trial of a self-assembling haemostatic gel to prevent delayed bleeding following endoscopic mucosal resection (PURPLE trial)

Gut. 2025;74(7):1104-1112

Drews J, Zachäus M, Kleemann T, Schirra J, Cahyadi O, Möschler O, Schulze C, Steinbrück I, Wedi E, Pech O, Weismüller TJ, Küllmer A, Abdelhafez M, Wedemeyer J, Beyna T, Riedel J, Halm UP, Güther C, Vasapolli R, Torres Reyes C, Quast DR, Bachmann O, Dedonaki E, Ulrich J, Marchuk I, Frahm C, Steffen T, Wohlmuth P, Bunde T, Geßler N, von Hahn T

Colon to Rectum

Clinical validation of a circulating tumor DNA-based blood test to screen for colorectal cancer

JAMA. 2025;334(1):56-63

Shaukat A, Burke CA, Chan AT, Grady WM, Gupta S, Katona BW, Ladabaum U, Liang PS, Liu JJ, Putcha G, Robertson DJ, Schoen RE, Meng Z, Piscitello A, Sun CK, Xu C, Lin CJ, Lee LC, Baldo L, Levin TR; PREEMPT CRC Investigators

Colon to Rectum

The efficacy of texture and color enhancement imaging observation in the detection of colorectal lesions: A multicenter, randomized controlled trial (deTXIon study)

Gastroenterology. 2025;169(2):337-345.e2

Toyoshima N, Sakamoto T, Shinmura K, Hotta K, Misawa M, Tamai N, Uraoka T, Matsuda T, Shibata T, Mizuguchi Y, Takamaru H, Nakamura K, Kakugawa Y, Shiroyama M, Kawagoe R, Tsuchiya K, Ikematsu H, Inaba A, Minakata N, Imai K, Takada K, Ito S, Wakamura K, Kudo SE, Sumiyama K, Ito M, Tomaru S, Fujimoto A, Saito Y